The asymmetric ester enolate Claisen rearrangement as a suitable method for the synthesis of sterically highly demanding amino acids

被引：51

作者：

Krebs, A ^{[1
]}

Kazmaier, U ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST ORGAN CHEM,D-69120 HEIDELBERG,GERMANY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 44期

关键词：

D O I：

10.1016/0040-4039(96)01764-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ester enolate Claisen rearrangement of highly substituted glycine allylic esters under the influence of chiral ligands gives rise to sterically demanding amino acids. The reaction yields amino acids with a beta-quaternary carbon center in a highly diastereo- and enantioselective manner, and could be applied to a wide scope of different classes of amino acids. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7945 / 7946

页数：2

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