Reduced expression of the adherens junction protein cadherin-5 in a diabetic retina

被引：31

作者：

Davidson, MK

Russ, PK

Glick, GG

Hoffman, LH

Chang, MS

Haselton, FR

机构：

[1] Vanderbilt Univ, Med Ctr, Sch Engn, Dept Biomed Engn,MCN, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Dept Cell Biol, Nashville, TN 37212 USA

[4] Vanderbilt Univ, Sch Med, Dept Ophthalmol & Visual Sci, Nashville, TN 37212 USA

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 2000年 / 129卷 / 02期

关键词：

D O I：

10.1016/S0002-9394(99)00323-2

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: Transvascular leakage occurs in diabetic retinopathy, The tight junction proteins occludin and zonula occludens-1 (ZO-1) and adherens junction protein cadherin-5 are critical to the maintenance of endothelial barrier. We report a comparison of junction protein expression in the normal and diabetic retina. METHOD: Case report. Postmortem retinal cryosections were prepared from the left eye of a 73-year-old woman with diabetic retinopathy. Cryosections were immunostained for cadherin-5, occludin, and ZO-1 and compared with retinal cryosections from the right eye of a 72-year-old man with no progression of retinal disease. RESULTS: Immunofluorescence showed positive retinal vessel staining for occludin and ZO-1 in both eyes and cadherin-5 in the normal eye but reduced cadherin-5 staining in the retinal vessels of the diabetic eye. CONCLUSION: Increases in transvascular leakage observed in diabetic retinal vasculature may be associated with reduction in the expression of the critical adherens junction protein, cadherin-5. (Am J Ophthalmol 2000;129:267-269, (C) 2000 by Elsevier Science Inc. All rights reserved.).

引用

页码：267 / 269

页数：3

共 5 条

[1] Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content - Vascular endothelial growth factor decreases occludin in retinal endothelial cells [J].