Complex formation between cationically modified gold nanoparticles and DNA: An atomic force microscopic study

被引：47

作者：

Ganguli, M ^{[1
]}

Babu, JV ^{[1
]}

Maiti, S ^{[1
]}

机构：

[1] CSIR, Inst Genom & Integrat Biol, Delhi 110007, India

来源：

LANGMUIR | 2004年 / 20卷 / 13期

关键词：

D O I：

10.1021/la036049a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Atomic force microscopy has been used for direct visualization of the wrapping of DNA around 30-nm-sized functionalized gold nanoparticles for the first time. The morphology of the complexes seems to be dictated by the relative concentration of the nanoparticles and DNA. A higher concentration of the former leads to the formation of a network of nanoparticles assembled on DNA. This assembly pattern seems to be significantly different from the manner in which cationically modified gold nanoparticles of smaller size (<5 nm) arrange linearly on DNA, as shown in the literature. A DNA-gold nanoparticle can be developed as a model system for in vitro studies on the mechanism of DNA condensation and also for developing novel methods of nanoparticle self-assembly on the DNA template.

引用

页码：5165 / 5170

页数：6

共 34 条

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