High mobility group box 1 protein, a cue for stem cell recruitment

被引:72
作者
Palumbo, R [1 ]
Bianchi, ME [1 ]
机构
[1] San Raffaele Univ, San Raffaele Res Inst, Dept Mol Biol & Funct Genom, I-20132 Milan, Italy
关键词
cell migration; cytokine; inflammation; stem cell; tissue damage; tissue regeneration;
D O I
10.1016/j.bcp.2004.03.048
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
High mobility group box I (HMGB1) is a non-histone protein required to maintain chromatin architecture. Recent observations demonstrated that HMGB I can also act as a cytokine to regulate different biological processes such as inflammation, cell migration and metastasis. We showed previously that HMGB I can be released passively by cells that die in a traumatic and unprogrammed way, and can serve a signal of tissue damage. More recently, we showed that HMGB I can recruit stem cells: HMGB1 induces stem cell transmigration through an endothelial barrier; moreover, when beads containing HMGB I are implanted into healthy muscle, they recruit stem cells injected into the general circulation. The inflammatory and tissue-regenerating roles of HMGB I may be strictly interconnected, and are discussed here. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:1165 / 1170
页数:6
相关论文
共 37 条
[1]   Cutting edge: HMG-1 as a mediator of acute lung inflammation [J].
Abraham, E ;
Arcaroli, J ;
Carmody, A ;
Wang, HC ;
Tracey, KJ .
JOURNAL OF IMMUNOLOGY, 2000, 165 (06) :2950-2954
[2]   HMGB proteins and gene expression [J].
Agresti, A ;
Bianchi, ME .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (02) :170-178
[3]   HMGB1 is a potent trigger of arthritis [J].
Andersson, U ;
Erlandsson-Harris, H .
JOURNAL OF INTERNAL MEDICINE, 2004, 255 (03) :344-350
[4]   High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes [J].
Andersson, U ;
Wang, HC ;
Palmblad, K ;
Aveberger, AC ;
Bloom, O ;
Erlandsson-Harris, H ;
Janson, A ;
Kokkola, R ;
Zhang, MH ;
Yang, H ;
Tracey, KJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) :565-570
[5]   Chromatin and cell death [J].
Bianchi, ME ;
Manfredi, A .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2004, 1677 (1-3) :181-186
[6]   Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion [J].
Bonaldi, T ;
Talamo, F ;
Scaffidi, P ;
Ferrera, D ;
Porto, A ;
Bachi, A ;
Rubartelli, A ;
Agresti, A ;
Bianchi, ME .
EMBO JOURNAL, 2003, 22 (20) :5551-5560
[7]  
Bustin M, 1999, MOL CELL BIOL, V19, P5237
[8]   The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice [J].
Calogero, S ;
Grassi, F ;
Aguzzi, A ;
Voigtländer, T ;
Ferrier, P ;
Ferrari, S ;
Bianchi, ME .
NATURE GENETICS, 1999, 22 (03) :276-280
[9]   Cardiomyocytes overexpressing TNF-α attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinase [J].
Chen, Y ;
Ke, QG ;
Yang, YK ;
Rana, JMS ;
Tang, J ;
Morgan, JP ;
Xiao, YF .
FASEB JOURNAL, 2003, 17 (15) :2231-2239
[10]   The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells [J].
Degryse, B ;
Bonaldi, T ;
Scaffidi, P ;
Müller, S ;
Resnati, M ;
Sanvito, F ;
Arrigoni, G ;
Bianchi, ME .
JOURNAL OF CELL BIOLOGY, 2001, 152 (06) :1197-1206