High mobility group box 1 protein, a cue for stem cell recruitment

被引：72

作者：

Palumbo, R ^{[1
]}

Bianchi, ME ^{[1
]}

机构：

[1] San Raffaele Univ, San Raffaele Res Inst, Dept Mol Biol & Funct Genom, I-20132 Milan, Italy

来源：

BIOCHEMICAL PHARMACOLOGY | 2004年 / 68卷 / 06期

关键词：

cell migration; cytokine; inflammation; stem cell; tissue damage; tissue regeneration;

D O I：

10.1016/j.bcp.2004.03.048

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High mobility group box I (HMGB1) is a non-histone protein required to maintain chromatin architecture. Recent observations demonstrated that HMGB I can also act as a cytokine to regulate different biological processes such as inflammation, cell migration and metastasis. We showed previously that HMGB I can be released passively by cells that die in a traumatic and unprogrammed way, and can serve a signal of tissue damage. More recently, we showed that HMGB I can recruit stem cells: HMGB1 induces stem cell transmigration through an endothelial barrier; moreover, when beads containing HMGB I are implanted into healthy muscle, they recruit stem cells injected into the general circulation. The inflammatory and tissue-regenerating roles of HMGB I may be strictly interconnected, and are discussed here. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1165 / 1170

页数：6

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