Isolation of handelin from Chrysanthemum boreale

被引：6

作者：

Kang, SS

Kim, JS

Son, KH

Lee, CO

Kim, YH

机构：

[1] ANDONG NATL UNIV,DEPT FOOD & NUTR,ANDONG 760749,SOUTH KOREA

[2] KOREA RES INST CHEM TECHNOL,PHARMACEUT SCREENING LAB,TAEJON 305606,SOUTH KOREA

[3] SANGJI UNIV,COLL NAT SCI,WONJU 220702,SOUTH KOREA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1996年 / 19卷 / 05期

关键词：

Chrysanthemum boreale; compositae; guaianolide dimer; handelin; NMR assignment; anti-tumor activity;

D O I：

10.1007/BF02976387

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The flowers of Chrysanthemum boreale afforded handelin, a unique guaianolide dimer and a mixture of n-hydrocarbons and n-hydrocarbon alcohols in addition to beta-sitosterol and beta-sitosterol glucoside. Detailed analysis of the H-1- and C-13-NMR spectra of handelin was carried out by the application of two-dimensional H-1- H-1-COSY and H-1- C-13 multiple-bond, multiple-quantum spectroscopic correlation techniques. Handelin was inactive in the in vitro anti-tumor activity.

引用

页码：406 / 410

页数：5

共 17 条

[1]

ASADA H, 1984, CHEM PHARM BULL, V32, P3036

[2] POLYACETYLENVERBINDUNGEN .28. UBER WEITERE POLYINE AUS DEM TRIBUS ANTHEMIDEAE L [J].