Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

被引：58

作者：

Bhutani, Utkarsh ^{[1
]}

Laha, Anindita ^{[1
]}

Mitra, Kishalay ^{[1
]}

Majumdar, Saptarshi ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem Engn, Hyderabad, Andhra Pradesh, India

来源：

MATERIALS LETTERS | 2016年 / 164卷

关键词：

Sodium Alginate; Gelatin; Piperine; Hydrogels; Viscosity; Plasticizer; DELIVERY;

D O I：

10.1016/j.matlet.2015.10.114

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：76 / 79

页数：4

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