Mechanisms linking obesity with cardiovascular disease

被引：2083

作者：

Van Gaal, Luc F. ^{[1
]}

Mertens, Ilse L. ^{[1
]}

De Block, Christophe E. ^{[1
]}

机构：

[1] Univ Antwerp, Univ Antwerp Hosp, Fac Med, Dept Diabetol Metab & Clin Nutr, B-2650 Antwerp, Belgium

来源：

NATURE | 2006年 / 444卷 / 7121期

关键词：

D O I：

10.1038/nature05487

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

引用

页码：875 / 880

页数：6

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