Meta- and pooled analysis of GSTT1 and lung cancer:: A HuGE-GSEC review

被引：109

作者：

Raimondi, S.

Paracchini, V.

Autrup, H.

Barros-Dios, J. M.

Benhamou, S.

Boffetta, P.

Cote, M. L.

Dialyna, I. A.

Dolzan, V.

Filiberti, R.

Garte, S.

Hirvonen, A.

Husgafvel-Pursiainen, K.

Imyanitov, E. N.

Kalina, I.

Kang, D.

Kiyohara, C.

Kohno, T.

Kremers, P.

Lan, Q.

London, S.

Povey, A. C.

Rannug, A.

Reszka, E.

Risch, A.

Romkes, M.

Schneider, J.

Seow, A.

Shields, P. G.

Sobti, R. C.

Sorensen, M.

Spinola, M.

Spitz, M. R.

Strange, R. C.

Stucker, I.

Sugimura, H.

To-Figueras, J.

Tokudome, S.

Yang, P.

Yuan, J-M.

Warholm, M.

Taioli, E.

机构：

[1] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15232 USA

[2] Policlin Milano, Milan, Italy

[3] Univ Aarhus, Inst Publ Hlth, DK-8000 Aarhus C, Denmark

[4] Univ Santiago de Compostela, Dept Prevent Med & Publ Hlth, Santiago De Compostela, Spain

[5] INSERM, Evry, France

[6] Evry Univ, Evry, France

[7] Int Agcy Res Canc, Genet & Epidemiol Cluster, F-69372 Lyon, France

[8] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48202 USA

[9] Univ Crete, Dept Virol, Iraklion, Greece

[10] Univ Ljubljana, Inst Biochem, Ljubljana 61000, Slovenia

[11] Natl Inst Canc Res, Dept Epidemiol & Biostat, Genoa, Italy

[12] Res Genet Inc, Milan, Italy

[13] Finnish Inst Occupat Hlth, Helsinki, Finland

[14] NN Petrov Oncol Res Inst, St Petersburg 188646, Russia

[15] Safarik Univ, Sch Med, Dept Med Biol, Kosice 04154, Slovakia

[16] Seoul Natl Univ, Inst Environm Med, Seoul 151, South Korea

[17] Kyushu Univ, Grad Sch Med Sci, Dept Prevent Med, Fukuoka 812, Japan

[18] Natl Inst Canc Res, Div Biol, Tokyo, Japan

[19] Inst Pathol, Serv Med Chem, Liege, Belgium

[20] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[21] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA

[22] Univ Manchester, Ctr Occupat & Environm Hlth, Manchester M13 9PL, Lancs, England

[23] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[24] Inst Occupat Med, Dept Toxicol & Carcinogenesis, Lodz, Poland

[25] DKFZ German Canc Res Ctr, Dept Toxicol & Canc Risk Factors, Heidelberg, Germany

[26] Univ Giessen, Inst Occupat & Social Med, D-35390 Giessen, Germany

[27] Natl Univ Singapore, Dept Community Occupat & Family Med, Singapore 117548, Singapore

[28] Georgetown Univ, Med Ctr, Canc Genet & Epidemiol, Washington, DC 20007 USA

[29] Panjab Univ, Dept Biotechnol, Chandigarh 160014, India

[30] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark

[31] Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

[32] Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[33] Univ Keele, N Staffordshire Hosp, Ctr Cell & Mol Med, Keele ST5 5BG, Staffs, England

[34] INSERM, Unit Epidemiol Stat Res Environm & Hlth, F-94800 Villejuif, France

[35] Hamamatsu Univ Sch Med, Dept Pathol 1, Hamamatsu, Shizuoka 43131, Japan

[36] Hosp Clin Prov Toxicol Unit, Barcelona, Spain

[37] Nagoya City Univ, Grad Sch Med Sci, Dept Hlth Promot & Prevent Med, Mizuho Ku, Nagoya, Aichi 467, Japan

[38] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN USA

[39] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN 55455 USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2006年 / 164卷 / 11期

关键词：

disease susceptibility; epidemiology; genes; genetic predisposition to disease; GSTT1; lung neoplasms; meta-analysis;

D O I：

10.1093/aje/kwj321

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

引用

页码：1027 / 1042

页数：16

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