PEG-linked luminescent platinum(II) complex as aqueous polymeric molecular light switch for protein binding reactions

被引：65

作者：

Che, CM

Zhang, JL

Lin, LR

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Inst Mol Technol Drug Discovery & Synth, Open Lab Chem Biol, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 21期

关键词：

D O I：

10.1039/b207395a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Attachment of poly(ethylene glycol) (PEG) to [Pt(4-HOPh-C<^>N<^>N)Cl] via covalent etheric bonds yields the luminescent polymer PEG-[Pt] (2), the photoluminescence of which is enhanced in hydrophobic regions of protein molecules (binding constant up to 10(4) M-1) in aqueous solution; complex 2 can function as a luminescent probe for protein denaturation due to urea unfolding reaction.

引用

页码：2556 / 2557

页数：2

共 21 条

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