Slit-Robo signaling

被引：262

作者：

Blockus, Heike ^{[1
,2
,3
]}

Chedotal, Alain ^{[1
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, CNRS, INSERM,Inst Vis, 17 Rue Moreau, F-75012 Paris, France

[2] Ecole Neurosci Paris, F-75005 Paris, France

[3] Columbia Univ, Dept Neurosci, Kavli Inst Brain Sci, 1108 NWC Bldg,550West 120th St, New York, NY 10027 USA

来源：

DEVELOPMENT | 2016年 / 143卷 / 17期

关键词：

Robo; Slit; Angiogenesis; Axon guidance; Development; Migration; CONTROL AXON REPULSION; HORIZONTAL GAZE PALSY; ROUNDABOUT RECEPTOR; BETA-CATENIN; GUIDANCE RECEPTORS; TYROSINE KINASE; REPELLENT SLIT; SHORT-RANGE; MIDLINE; DROSOPHILA;

D O I：

10.1242/dev.132829

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Slits are secreted proteins that bind to Roundabout ( Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. Here, we summarize new insights into Slit-Robo evolutionary and system-dependent diversity, receptor-ligand interactions, signaling crosstalk and receptor activation.

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收藏

页码：3037 / 3044

页数：8

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