Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct γ-Oh-1,N2-propano-2′-deoxyguanosine

被引：48

作者：

Kim, HYH

Voehler, M

Harris, TM

Stone, MP

机构：

[1] Vanderbilt Univ, Dept Chem, Ctr Mol Toxicol, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37235 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 32期

关键词：

D O I：

10.1021/ja020333r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spectroscopic evidence is presented for the formation of a carbinolamine interchain cross-link in 5′-CpG-3′ sequences, arising from the acrolein adduct γ-OH-PdG. This may be important in understanding biological processing of acrolein-induced DNA damage in CpG sequences. Copyright © 2002 American Chemical Society.

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页码：9324 / 9325

页数：2

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