High-dose carmustine for high-grade gliomas in childhood

被引：29

作者：

Bouffet, E

Khelfaoui, F

Philip, I

Biron, P

BrunatMentigny, M

Philip, T

机构：

[1] CTR LEON BERARD, DEPT PEDIAT, F-69373 LYON 08, FRANCE

[2] CTR LEON BERARD, DEPT INTENS CHEMOTHERAPY & BONE MARROW TRANSPLANT, F-69373 LYON 08, FRANCE

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1997年 / 39卷 / 04期

关键词：

BCNU; autologous bone marrow transplantation; child; high-grade glioma;

D O I：

10.1007/s002800050586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Carmustine (BCNU) has proved to be of value against a variety of primary brain tumors. This agent exhibits a steep dose-response curve in in vitro and animal tumor models and has been proposed for use in high-dose chemotherapy as a single agent or in combination. We conducted a phase II study to assess high-dose BCNU in children with high-grade gliomas. A total of 13 children with high-grade gliomas were treated in a phase II study using high-dose BCNU (800 mg/m(2)) followed by autologous bone marrow transplantation. Eight patients were newly diagnosed, and five were treated at the time of tumor recurrence. Seven patients had diffuse intrinsic brain-stem gliomas. The response was assessed at 1 month after treatment. Only one objective effect was observed. Five patients had stable disease and seven progressed. The immediate toxicity was mild; however, one patient developed fatal respiratory distress at 50 days after treatment with high-dose BCNU. Dose escalation of BCNU does not seem beneficial in children with high-grade gliomas.

引用

页码：376 / 379

页数：4

共 28 条

[1]

BIRON P, 1995, AUTOLOGOUS MARROW BL, P451

[2] HIGH-DOSE BCNU FOLLOWED BY AUTOLOGOUS BONE-MARROW INFUSION IN GLIOBLASTOMA-MULTIFORME [J].

CARELLA, AM ;

GIORDANO, D ;

SANTINI, G ;

FRASSONI, F ;

PODESTA, M ;

VANLINT, MT ;

BACIGALUPO, A ;

NATI, S ;

VIMERCATI, R ;

OCCHINI, D ;

BISTOLFI, F ;

LUCARELLI, G ;

LERCARI, G ;

MARMONT, AM .

TUMORI, 1981, 67 (05) :473-475

[3]

FINE HA, 1993, CANCER, V71, P2585, DOI 10.1002/1097-0142(19930415)71:8<2585::AID-CNCR2820710825>3.0.CO

[4]

2-S

[5] HIGH-DOSE MULTIAGENT CHEMOTHERAPY FOLLOWED BY BONE-MARROW RESCUE FOR MALIGNANT ASTROCYTOMAS OF CHILDHOOD AND ADOLESCENCE [J].

FINLAY, JL ;

AUGUST, C ;

PACKER, R ;

ZIMMERMAN, R ;

SUTTON, L ;

FREID, A ;

RORKE, L ;

BAYEVER, E ;

KAMANI, N ;

KRAMER, E ;

COHEN, B ;

STURGILL, B ;

NACHMAN, J ;

STRANDJORD, S ;

TURSKI, P ;

FRIERDICH, S ;

STEEVES, R ;

JAVID, M .

JOURNAL OF NEURO-ONCOLOGY, 1990, 9 (03) :239-248

[6] HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS BONE-MARROW RESCUE FOLLOWED BY INTERSTITIAL AND EXTERNAL-BEAM RADIOTHERAPY IN NEWLY-DIAGNOSED PEDIATRIC MALIGNANT GLIOMAS [J].

HEIDEMAN, RL ;

DOUGLASS, EC ;

KRANCE, RA ;

FONTANESI, J ;

LANGSTON, JA ;

SANFORD, RA ;

KOVNAR, EH ;

OCHS, J ;

KUTTESCH, J ;

JENKINS, JJ ;

FAIRCLOUGH, DL ;

KUN, LE .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (08) :1458-1465

[7] PROLONGATION OF SURVIVAL FOR HIGH-GRADE MALIGNANT GLIOMAS WITH ADJUVANT HIGH-DOSE BCNU AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION [J].

JOHNSON, DB ;

THOMPSON, JM ;

CORWIN, JA ;

MOSLEY, KR ;

SMITH, MT ;

DELOSREYES, RA ;

DALY, MB ;

PETTY, AM ;

LAMASTER, D ;

PIERSON, WP ;

RUXER, RL ;

LEFF, RS ;

MESSERSCHMIDT, GL .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (05) :783-789

[8]

KALIFA C, 1992, BONE MARROW TRANSPL, V9, P227

[9] HIGH-DOSE CHEMOTHERAPY WITH MARROW REINFUSION AND HYPERFRACTIONATED IRRADIATION FOR CHILDREN WITH HIGH-RISK BRAIN-TUMORS [J].

KEDAR, A ;

MARIA, BL ;

GRAHAMPOLE, J ;

RINGDAHL, DM ;

QUISLING, RG ;

MICKLE, JP ;

MENDENHALL, NP ;

MARCUS, RB ;

GROSS, S .

MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 23 (05) :428-436

[10] HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS BONE-MARROW RESCUE FOR HIGH-GRADE GLIOMAS OF THE BRAIN - A POTENTIAL FOR IMPROVEMENT IN THERAPEUTIC RESULTS [J].

KESSINGER, A .

NEUROSURGERY, 1984, 15 (05) :747-750

← 1 2 3 →