Pathogenesis of venous thromboembolism

被引：34

作者：

Becattini, C ^{[1
]}

Agnelli, G ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Med Interna, Sez Med Interna & Cardiocasc, I-06126 Perugia, Italy

来源：

CURRENT OPINION IN PULMONARY MEDICINE | 2002年 / 8卷 / 05期

关键词：

D O I：

10.1097/00063198-200209000-00003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Three factors are related with the pathogenesis of venous thrombosis: (1) blood stasis, (2) hypercoagulability, and (3) vessel damage. Local and systemic factors are implicated in blood stasis. Remarkable advances have been recently achieved regarding the understanding of the concept of hypercoagulability, with special emphasis to thrombophilic molecular abnormalities. Increased thromboembolic risk has been described in patients with antithrombin III, protein C, or protein S deficiencies as well as factor V Leiden, prothrombin mutation G2021 0A, or hyperhomocystinemia. Vessel wall has a remarkable role in protecting against and in promoting thrombosis. The role of inflammation on venous thrombosis is under investigation. (C) 2002 Lippincott Williams Wilkins, Inc.

引用

页码：360 / 364

页数：5

共 39 条

[1]

Alhenc-Gelas M, 1999, THROMB HAEMOSTASIS, V81, P506

[2]

[Anonymous], 1994, Hemostasis and thrombosis: basic principle and clinical practice

[3]

INFLUENCE OF ARTERIAL DAMAGE AND WALL SHEAR RATE ON PLATELET DEPOSITION - EXVIVO STUDY IN A SWINE MODEL [J].