Molecular cytogenetic aspects of hematological malignancies: Clinical implications

被引:37
作者
Chen, Z
Sandberg, AA
机构
[1] Univ Utah, Sch Med, Dept Pediat, Div Med Genet,Cytogenet Lab, Salt Lake City, UT 84132 USA
[2] St Josephs Hosp, Dept DNA Diagnost, Phoenix, AZ USA
[3] Med Ctr, Phoenix, AZ USA
[4] Univ Arizona, Tucson, AZ 85721 USA
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 2002年 / 115卷 / 03期
关键词
molecular cytogenetics; chromosomal abnormalities; hematological malignancies;
D O I
10.1002/ajmg.10689
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The field of molecular cytogenetics has had a great impact on many aspects of medical and basic sciences. During the past 30 years, the application of molecular cytogenetic methodologies has resulted in remarkable advances in the field of cancer genetics and cytogenetics. These advances have led to the establishment of chromosome patterns as diagnostic and prognostic indexes in an array of acute and chronic leukemias and lymphomas, as key information in BMT, and as guides for the localization of oncogenes and tumor suppressor genes that are apparently responsible for the development of neoplastic states. With such information, the physician is in a more favorable position to devise therapy, appraise diagnosis, and plan follow-up. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:130 / 141
页数:12
相关论文
共 44 条
[1]   MYELOPROLIFERATIVE DISORDER ASSOCIATED WITH 8P11 TRANSLOCATIONS [J].
AGUIAR, RCT ;
MACDONALD, D ;
MASON, PJ ;
CROSS, NCP ;
GOLDMAN, JM .
BLOOD, 1995, 86 (02) :834-835
[2]  
[Anonymous], CHROMOSOMES HUMAN CA
[3]   Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia [J].
BenYehuda, D ;
Krichevsky, S ;
Rachmilewitz, EA ;
Avraham, A ;
Palumbo, GA ;
Frassoni, F ;
Sahar, D ;
Rosenbaum, H ;
Paltiel, O ;
Zion, M ;
Ben-Neriah, Y .
BLOOD, 1997, 90 (12) :4918-4923
[4]   Chromosome aberrations in atypical chronic lymphocytic leukemia: a cytogenetic and interphase cytogenetic study [J].
Bigoni, R ;
Cuneo, A ;
Roberti, MG ;
Bardi, A ;
Rigolin, GM ;
Piva, N ;
Scapoli, G ;
Spanedda, R ;
Negrini, M ;
Bullrich, F ;
Veronese, ML ;
Croce, CM ;
Castoldi, G .
LEUKEMIA, 1997, 11 (11) :1933-1940
[5]   Telomere length shortening in chronic myelogenous leukemia is associated with reduced time to accelerated phase [J].
Boultwood, J ;
Peniket, A ;
Watkins, F ;
Shepherd, P ;
McGale, P ;
Richards, S ;
Fidler, C ;
Littlewood, TJ ;
Wainscoat, JS .
BLOOD, 2000, 96 (01) :358-361
[6]  
Caligiuri MA, 1998, CANCER RES, V58, P55
[7]  
CATALAND SR, 2001, ONCOL SPECTRUMS, V9, P617
[8]  
Chen Z, 1998, GENE CHROMOSOME CANC, V22, P321, DOI 10.1002/(SICI)1098-2264(199808)22:4<321::AID-GCC8>3.0.CO
[9]  
2-X
[10]   UNIQUE FORMS OF THE ABL TYROSINE KINASE DISTINGUISH PH1-POSITIVE CML FROM PH1-POSITIVE ALL [J].
CLARK, SS ;
MCLAUGHLIN, J ;
CRIST, WM ;
CHAMPLIN, R ;
WITTE, ON .
SCIENCE, 1987, 235 (4784) :85-88