Regulation of cell function by Rho family GTPases

被引：80

作者：

Bokoch, GM

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

IMMUNOLOGIC RESEARCH | 2000年 / 21卷 / 2-3期

关键词：

Rho GTPases; kinases; neutrophils; actin cytoskeleton; signal transduction; cell death; oxidants;

D O I：

10.1385/IR:21:2-3:139

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effecters to modulate cell function, and how these events are coordinated in the stimulated cell. Areas of major interest include NADPH oxidase regulation by Rac2, Rac- and Cdc42-mediated control of the actin-myosin cytoskeleton via p21-activated kinase (PAK), and modulation of the apoptotic program by Rho GTPases and PAK.

引用

页码：139 / 148

页数：10

共 42 条

[1] PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
Abo, A
Qu, J
Cammarano, MS
Dan, CT
Fritsch, A
Baud, V
Belisle, B
Minden, A
[J]. EMBO JOURNAL, 1998, 17 (22) : 6527 - 6540
[2] PAK3 mutation in nonsyndromic X-linked mental retardation
Allen, KM
Gleeson, JG
Bagrodia, S
Partington, MW
MacMillan, JC
Cerione, RA
Mulley, JC
Walsh, CA
[J]. NATURE GENETICS, 1998, 20 (01) : 25 - 30
[3] Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
Arber, S
Barbayannis, FA
Hanser, H
Schneider, C
Stanyon, CA
Bernard, O
Caroni, P
[J]. NATURE, 1998, 393 (6687) : 805 - 809
[4] A novel regulator of p21-activated kinases
Bagrodia, S
Taylor, SJ
Jordon, KA
Van Aelst, L
Cerione, RA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) : 23633 - 23636
[5] Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
Benard, V
Bohl, BP
Bokoch, GM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) : 13198 - 13204
[6] IDENTIFICATION OF NOVEL GTP-BINDING PROTEINS IN THE HUMAN NEUTROPHIL
BOKOCH, GM
PARKOS, CA
[J]. FEBS LETTERS, 1988, 227 (01) : 66 - 70
[7] Interplay between Ras-related and heterotrimeric GTP binding proteins: Lifestyles of the BIG and little
Bokoch, GM
[J]. FASEB JOURNAL, 1996, 10 (11) : 1290 - 1295
[8] BOKOCH GM, 1988, J BIOL CHEM, V263, P16744
[9] REGULATION OF THE PHAGOCYTE RESPIRATORY BURST BY SMALL GTP-BINDING PROTEINS
BOKOCH, GM
[J]. TRENDS IN CELL BIOLOGY, 1995, 5 (03) : 109 - 113
[10] CHEMOATTRACTANT SIGNALING AND LEUKOCYTE ACTIVATION
BOKOCH, GM
[J]. BLOOD, 1995, 86 (05) : 1649 - 1660

← 1 2 3 4 5 →