Expression of α-calcitonin gene-related peptide in the enteric nervous system of rat small intestine

被引：11

作者：

Doi, Y

Peng, H

Kudo, H

Hamasaki, K

Fujimoto, S

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Anat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

[2] Univ Occupat & Environm Hlth, Sch Hlth Sci, Dept Clin Pathol, Kitakyushu, Fukuoka 8078555, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 285卷 / 01期

关键词：

alpha-calcitonin gene-related peptide; enteric nervous system; small intestine; in situ hybridization; reverse transcriptase polymerase; chain reaction; Rat;

D O I：

10.1016/S0304-3940(00)01018-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We first detected ol-calcitonin gene-related peptide (alpha-CGRP) precursor mRNA in the enteric nervous system (ENS) of rat small intestine by reverse transcriptase polymerase chain reaction (RT-PCR). The nucleotide sequence of the RT-PCR product was completely identical to that found in other organs. fly in situ hybridization using digoxygenin-labeled alpha-CORP precursor cRNA probe, we found that antisense probes detected a signal on nerve cell bodies of both submucosal and myenteric plexuses. Our findings indicate that the rat ENS participates in synthesis of alpha-CGRP precursor. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：33 / 36

页数：4

共 20 条

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