Higher C-reactive protein concentration and white blood cell count in subjects with more coronary risk factors and/or lower physical fitness among apparently healthy Japanese

Of 2,722 people (1,876 men, mean age: 51.3+/-10.3 years; 846 women, mean age: 51.4+/-11.1) who underwent the fitness check program at Aichi Prefectural Center for Health Care, the concentration of C-reactive protein (CRP) and the white blood cell count (WBC) were investigated in relation to the number of coronary risk factors, maximum oxygen uptake (VO2max) quartiles and physical fitness score. CRP was measured by conventional latex immunoturbidimetric assay. Both CRP and WBC were higher in those who had more risk factors. In men the lowest mean CRP was 0.07 mg/dl in those with only one risk factor (RF1) and the highest was 0.29 mg/dl in RF6 (p<0.0001). The lowest mean WBC was 4,868/mm(3),in RF1 and the highest was 7,096/mm(3) in RF6 (p<0.0001). In women the lowest mean CRP was 0.073 mg/dl in those with no risk factors (RF0) and the highest was 0.22mg/dl in RF5 (P=0.0379). The lowest mean WBC was 5,065/mm(3) in RF1, and the highest was 6,792/mm(3) in RF4 (p=0.0001). A similar relationship was noticed when the groups were analyzed by VO2max quartile or fitness score. CRP and WBC both showed a stepwise increase or decrease in men, but was generally in order in women in accordance with the number of risk factors, VO2max level or fitness score. In apparently healthy Japanese subjects, elevated inflammatory indices (ie, higher CRP and WBC) were associated with more coronary risk factors and poorer physical fitness. Therefore, high-risk coronary subjects might be screened by conventional measurement of CRP.