Morphology and properties of poly vinyl alcohol (PVA) scaffolds: Impact of process variables

被引：59

作者：

Ye, Mao ^{[1
]}

Mohanty, Pravansu ^{[1
]}

Ghosh, Gargi ^{[1
]}

机构：

[1] Univ Michigan, Dept Mech Engn, Dearborn, MI 48128 USA

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2014年 / 42卷

关键词：

PVA scaffold; Foaming; Surfactant Freeze drying; Interconnected micro-pores; CROSS-LINKED PVA; CELL-GROWTH; HYDROGELS; FABRICATION; MEMBRANES; DESIGN;

D O I：

10.1016/j.msec.2014.05.029

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Successful engineering of functional biological substitutes requires scaffolds with three-dimensional interconnected porous structure, controllable rate of biodegradation, and ideal mechanical strength. In this study, we report the development and characterization of micro-porous PVA scaffolds fabricated by freeze drying method. The impact of molecular weight of PVA, surfactant concentration, foaming time, and stirring speed on pore characteristics, mechanical properties, swelling ratio, and rate of degradation of the scaffolds was characterized. Results show that a foaming time of 60 s, a stirring speed of 1000 rpm, and a surfactant concentration of 5% yielded scaffolds with rigid structure but with interconnected pores. Study also demonstrated that increased foaming time increased porosity and swelling ratio and reduced the rigidity of the samples. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：289 / 294

页数：6

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