Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4(+) T cells

被引：175

作者：

Carroll, RG

Riley, JL

Levine, BL

Feng, Y

Kaushal, S

Ritchey, DW

Bernstein, W

Weislow, OS

Brown, CR

Berger, EA

June, CH

StLouis, DC

机构：

[1] HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850

[2] USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20889

[3] WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850

[4] NIAID,VIRAL DIS LAB,NIH,BETHESDA,MD 20889

[5] SRA TECHNOL,ROCKVILLE,MD 20850

[6] NIAID,INFECT DIS LAB,NIH,ROCKVILLE,MD 20852

来源：

SCIENCE | 1997年 / 276卷 / 5310期

关键词：

D O I：

10.1126/science.276.5310.273

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-I, Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.

引用

页码：273 / 276

页数：4

共 51 条

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PRODUCTION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED RETROVIRUS IN HUMAN AND NONHUMAN CELLS TRANSFECTED WITH AN INFECTIOUS MOLECULAR CLONE [J].