Structural characterization of genomes by large scale sequence-structure threading: application of reliability analysis in structural genomics

被引:21
作者
Cherkasov, A [1 ]
Sui, SJH
Brunham, RC
Jones, SJM
机构
[1] Univ British Columbia, Fac Med, Div Infect Dis, Vancouver, BC, Canada
[2] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada
[3] Univ British Columbia, Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada
[4] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada
关键词
D O I
10.1186/1471-2105-5-101
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
described with a Weibull function. Systems which exhibit Weibull character can be interpreted with reliability theory commonly used in engineering analysis. For instance, Weibull distributions are widely used in reliability, maintainability and safety work to model time-to-failure of mechanical devices, mechanisms, building constructions and equipment. Results: We have found that the Weibull function describes protein fold distribution within and among genomes more accurately than conventional power functions which have been used in a number of structural genomic studies reported to date. It has also been found that the Weibull reliability parameter beta for protein fold distributions varies between genomes and may reflect differences in rates of gene duplication in evolutionary history of organisms. Conclusions: The results of this work demonstrate that reliability analysis can provide useful insights and testable predictions in the fields of comparative and structural genomics..,.
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页数:10
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