A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter

被引:296
作者
Pereira, LA [1 ]
Bentley, K [1 ]
Peeters, A [1 ]
Churchill, MJ [1 ]
Deacon, NJ [1 ]
机构
[1] Macfarlane Burnet Ctr Med Res, Natl Ctr HIV Virol Res, AIDS Mol Biol Unit, Fairfield, Vic 3078, Australia
关键词
D O I
10.1093/nar/28.3.663
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. To date a large number of sequence-specific DNA-protein interactions have been described for the HIV-1 LTR. The aim of this report is to provide a comprehensive, updated listing of these HIV-1 LTR interactions, It is intended as a reference point to facilitate on-going studies characterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replication.
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页码:663 / 668
页数:6
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