Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia

被引：276

作者：

Fine, LG ^{[1
]}

Bandyopadhyay, D ^{[1
]}

Norman, JT ^{[1
]}

机构：

[1] Royal Free & UCL Sch Med, Dept Med, London, England

来源：

KIDNEY INTERNATIONAL | 2000年 / 57卷

关键词：

progressive renal disease; proteinuria; hypoxia; fibrosis; tubulointerstitium;

D O I：

10.1046/j.1523-1755.2000.07512.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The question of why chronic renal diseases progress is a topic only recently investigated. Putative causes such as proteinuria do not account for all aspects of progressive renal disease. An alternative mechanism, chronic hypoxia, is proposed that might better explain certain elements of progressive renal disease, but elements of the hypothesis remain subject to further study.

引用

页码：S22 / S26

页数：5

共 26 条

[1] ANDERSON S, 1989, Q J MED, V70, P185
[2] Forefronts in nephrology: Oxygen sensing on the cellular and molecular levels - Regensburg, Germany June 23-26, 1996 - Introduction
Bauer, C
Kurtz, A
[J]. KIDNEY INTERNATIONAL, 1997, 51 (02) : 371 - 371
[3] LONG-TERM EFFECTS OF A CONVERTING-ENZYME-INHIBITOR AND A CALCIUM-CHANNEL BLOCKER ON URINARY ALBUMIN EXCRETION IN PATIENTS WITH ESSENTIAL-HYPERTENSION
BIGAZZI, R
BIANCHI, S
BALDARI, D
SGHERRI, G
BALDARI, G
CAMPESE, VM
[J]. AMERICAN JOURNAL OF HYPERTENSION, 1993, 6 (02) : 108 - 113
[4] MATRIX METALLOPROTEINASES - A REVIEW
BIRKEDALHANSEN, H
MOORE, WGI
BODDEN, MK
WINDSOR, LJ
BIRKEDALHANSEN, B
DECARLO, A
ENGLER, JA
[J]. CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (02) : 197 - 250
[5] THE OBLITERATION OF THE POST-GLOMERULAR CAPILLARIES AND ITS INFLUENCE UPON THE FUNCTION OF BOTH GLOMERULI AND TUBULI - FUNCTIONAL INTERPRETATION OF MORPHOLOGIC FINDINGS
BOHLE, A
VONGISE, H
MACKENSENHAEN, S
STARKJAKOB, B
[J]. KLINISCHE WOCHENSCHRIFT, 1981, 59 (18): : 1043 - 1051
[6] THE LONG-TERM PROGNOSIS OF THE PRIMARY GLOMERULONEPHRITIDES - A MORPHOLOGICAL AND CLINICAL ANALYSIS OF 1747 CASES
BOHLE, A
WEHRMANN, M
BOGENSCHUTZ, O
BATZ, C
VOGL, W
SCHMITT, H
MULLER, CA
MULLER, GA
[J]. PATHOLOGY RESEARCH AND PRACTICE, 1992, 188 (07) : 908 - 924
[7] TGF-beta in kidney fibrosis: A target for gene therapy
Border, WA
Noble, NA
[J]. KIDNEY INTERNATIONAL, 1997, 51 (05) : 1388 - 1396
[8] Oxygen sensing and molecular adaptation to hypoxia
Bunn, HF
Poyton, RO
[J]. PHYSIOLOGICAL REVIEWS, 1996, 76 (03) : 839 - 885
[9] Burton CJ, 1996, NEPHROL DIAL TRANSPL, V11, P1505
[10] TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP, AKA EPA) - STRUCTURE, CONTROL OF EXPRESSION AND BIOLOGICAL FUNCTIONS
DENHARDT, DT
FENG, B
EDWARDS, DR
COCUZZI, ET
MALYANKAR, UM
[J]. PHARMACOLOGY & THERAPEUTICS, 1993, 59 (03) : 329 - 341

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