New insights into the immunopathogenesis of chronic hepatitis C

被引：19

作者：

Diepolder, Helmut. M. ^{[1
]}

机构：

[1] Univ Munich, Dept Med 2, Munich, Germany

来源：

ANTIVIRAL RESEARCH | 2009年 / 82卷 / 03期

关键词：

Hepatitis C; Regulatory T cells; PD-1; Immunotherapy; REGULATORY T-CELLS; VIRUS (HCV)-SPECIFIC CD8(+); CELLULAR IMMUNE-RESPONSES; ACUTE HCV INFECTION; EX-VIVO ANALYSIS; PD-1; EXPRESSION; NONSTRUCTURAL PROTEIN-3; FUNCTIONAL SUPPRESSION; PERIPHERAL-BLOOD; VIRAL CLEARANCE;

D O I：

10.1016/j.antiviral.2009.02.203

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite the high propensity of hepatitis C virus to establish chronic viral persistence, immune-mediated viral clearance occurs in some patients, fostering hopes that therapeutic induction of specific antiviral immune responses might be able to contribute to viral clearance in chronically infected patients. Indeed, recent clinical trials of therapeutic vaccination have provided clear proof of concept that specific immunotherapy can reduce the viral load in some patients. Further improvement of these strategies will depend on a detailed analysis of the immunopathogenesis of chronic hepatitis C. Recent advances in our understanding of the mechanisms of down-regulation of virus-specific immune responses during chronic infection, including the role of regulatory T cells and inhibitory molecules such as programmed death receptor 1, may open up new avenues for second-generation immunotherapeutic interventions. (C) 2009 Elsevier B.V. All rights reserved

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页码：103 / 109

页数：7

相关论文

共 79 条

[1] Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor β that can suppress HCV-specific T-cell responses [J].

Alatrakchi, Nadia ;

Graham, Camilla S. ;

van der Vliet, Hans J. J. ;

Sherman, Kenneth E. ;

Exley, Mark A. ;

Koziel, Margaret James .

JOURNAL OF VIROLOGY, 2007, 81 (11) :5882-5892

[2] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[3] T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection [J].

Boettler, T ;

Spangenberg, HC ;

Neumann-Haefelin, C ;

Panther, E ;

Urbani, S ;

Ferrari, C ;

Blum, HE ;

von Weizsäcker, F ;

Thimme, R .

JOURNAL OF VIROLOGY, 2005, 79 (12) :7860-7867

[4] Increased hepatitis C virus (HCV)-specific CD4+CD25 + regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels [J].

Bolacchi, F ;

Sinistro, A ;

Ciaprini, C ;

Demin, F ;

Capozzi, M ;

Carducci, FC ;

Drapeau, CMJ ;

Rocchi, G ;

Bergamini, A .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 144 (02) :188-196

[5] Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection [J].

Bowen, David G. ;

Shoukry, Naglaa H. ;

Grakoui, Arash ;

Fuller, Michael J. ;

Cawthon, Andrew G. ;

Dong, Christine ;

Hasselschwert, Dana L. ;

Brasky, Kathleen M. ;

Freeman, Gordon J. ;

Seth, Nilufer P. ;

Wucherpfernnig, Kai W. ;

Houghton, Michael ;

Walker, Christopher M. .

JOURNAL OF VIROLOGY, 2008, 82 (10) :5109-5114

[6] Mutational escape from CD8+ T cell immunity:: HCV evolution, from chimpanzees to man [J].

Bowen, DG ;

Walker, CM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (11) :1709-1714

[7] An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection [J].

Cabrera, R ;

Tu, ZK ;

Xu, YL ;

Firpi, RJ ;

Rosen, HR ;

Liu, C ;

Nelson, DR .

HEPATOLOGY, 2004, 40 (05) :1062-1071

[8]

Chang KM, 1999, J IMMUNOL, V162, P1156

[9] Regulatory T cells in hepatitis C virus infection [J].

Chang, Kyong-Mi .

HEPATOLOGY RESEARCH, 2007, 37 :S327-S330

[10] Cellular immune selection with hepatitis C virus persistence in humans [J].

Cox, AL ;

Mosbruger, T ;

Mao, Q ;

Liu, Z ;

Wang, XH ;

Yang, HC ;

Sidney, J ;

Sette, A ;

Pardoll, D ;

Thomas, DL ;

Ray, SC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (11) :1741-1752

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