Solid-phase organic chemistry:: Synthesis of 2β-(heterocyclylthiomethyl)penam derivatives on solid support

被引：4

作者：

Delpiccolo, CML ^{[1
]}

Mata, EG ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis, RA-2000 Rosario, Santa Fe, Argentina

来源：

MOLECULES | 2000年 / 5卷 / 03期

关键词：

D O I：

10.3390/50300537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 2 beta-(heterocyclylthiomethyl)penam derivatives on solid support has been developed. Compounds are obtained in good to high yields (based on loading of the original resin). The key step is the solid-phase double rearrangement of the corresponding penicillin sulfoxide.

引用

页码：537 / 538

页数：2

共 4 条

[1] BUNIN BA, 1998, COMBINATORIAL INDEX
[2] DEWITT SH, 1997, PRACTICAL COMBINATOR
[3] Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant Staphylococcus aureus
Hecker, SJ
Cho, IS
Glinka, TW
Zhang, ZJ
Price, ME
Lee, VJ
Christensen, BG
Boggs, A
Chamberland, S
Malouin, F
Parr, TR
Annamalai, T
Blais, J
Bond, EL
Case, L
Chan, C
Crase, J
Frith, R
Griffith, D
Harford, L
Liu, N
Ludwikow, M
Mathias, K
Rea, D
Williams, R
[J]. JOURNAL OF ANTIBIOTICS, 1998, 51 (08) : 722 - 734
[4] beta-lactams on solid support: Mild and efficient removal of penicillin derivatives from Merrifield resin using aluminum chloride
Mata, EG
[J]. TETRAHEDRON LETTERS, 1997, 38 (36) : 6335 - 6338

← 1 →