Inhibition of UDP-Gal mutase and mycobacterial galactan biosynthesis by pyrrolidine analogues of galactofuranose

被引：110

作者：

Lee, RE

Smith, MD

Nash, RJ

Griffiths, RC

McNeil, M

Grewal, RK

Yan, WX

Besra, GS

Brennan, PJ

Fleet, GWJ

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] AFRC,INST GRASSLAND & ENVIRONM RES,ABERYSTWYTH SY23 3EB,DYFED,WALES

[3] COLORADO STATE UNIV,DEPT MICROBIOL,FT COLLINS,CO 80523

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(97)01539-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some pyrrolidine analogues of galactofuranose - synthesised from carbohydrate lactones - are the first known inhibitors of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis.:This inhibition may form a new chemotherapeutic strategy for the treatment of human pathogens which contain integral galactofuranosyl structures such as tuberculosis and leprosy. (C) 1997 Elsevier Science Ltd.

引用

页码：6733 / 6736

页数：4

共 16 条

[1] A SHORT, VERSATILE APPROACH TO POLYHYDROXYLATED PYRROLIDINES UTILIZING A REDUCTIVE ELIMINATION REDUCTIVE AMINATION AS A KEY STEP [J].