Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

被引：112

作者：

Powers, JP ^{[1
]}

Li, SY ^{[1
]}

Jaen, JC ^{[1
]}

Liu, JQ ^{[1
]}

Walker, NPC ^{[1
]}

Wang, ZL ^{[1
]}

Wesche, H ^{[1
]}

机构：

[1] Amgen Inc, 1120 Vet Blvd, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期

关键词：

IRAK-4; kinase; inflammation; kinase inhibitor;

D O I：

10.1016/j.bmcl.2006.03.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2842 / 2845

页数：4

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