Survivin-3B promotes chemoresistance and immune escape by inhibiting caspase-8 and-6 in cancer cells

被引：16

作者：

Vegran, Frederique ^{[1
]}

Boidot, Romain ^{[2
]}

机构：

[1] INSERM, U866, Dept Tumor Biol & Pathol, Mol Biol Unit, Dijon, France

[2] Ctr Georges Francois Leclerc, Dept Tumor Biol & Pathol, Mol Biol Unit, Dijon, France

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 11期

关键词：

caspase-6; caspase-8; survivin-3B; tumorigenesis; tumor escape; treatment response; SPLICE VARIANT; EXPRESSION;

D O I：

10.4161/onci.26328

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Survivin-3B (S-3B), an alternative splice isoform of survivin, plays a key role in tumorigenesis. S-3B promotes the escape of malignant cells from immune recognition by blocking the cytotoxicity of natural killer (NK) cells. Such an effect reflects the ability of S-3B to interfere with the assembly of the so-called "death-inducing signaling complex" upon the interaction of FAS with its ligand (FASL). S-3B also inhibits the activation of caspase-6, thus increasing the resistance of neoplastic cells to granzyme B and various chemotherapeutics.

引用

页数：3

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