Effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti-tumor role

被引:13
作者
Fu, Li-Ran [1 ]
Guo, Sheng-Wei [2 ]
Liu, Xian-Hui [2 ]
机构
[1] Southern Med Univ, People Hosp, Dept Internal TCM Med, Zhengzhou 450000, Peoples R China
[2] Henan Hosp TCM, Affiliated Hosp 2, Tumor Surg Dept, Zhengzhou 450000, Peoples R China
关键词
Yiqi Jianpi; Anti-cancer treatment; Intestinal cancer; Spleen-qi deficiency; COMBINATION TREATMENT; EMBOLIC STROKE; RATS; NEUROPROTECTION;
D O I
10.1016/S1995-7645(14)60059-6
中图分类号
R1 [预防医学、卫生学];
学科分类号
100235 [预防医学];
摘要
Objective: observe the effect of Yiqi Jianpi plus anticancer herbs on spleen deficiency in colorectal cancer and its anti tumor role. Methods: Human intestinal cancer cell HT29 xenograft of nude mice model was established. The expression of EGF, VEGF, gastric cancer tumor growth in mice were observed. Results: Protein kinase C expression in in the Yiqi Jianpi group and Yiqi Jianpi anti tumor group was significantly better than the model group (P<0.01, P<0.05). There was significantly more apoptotic cells in Yiqi Jianpi anti tumor group than Yiqi Jianpi group and model group (P<0.01). Epidermal growth factor and vascular endothelial growth factor expression in Yiqi Jianpi group was significantly lower than Yiqi Jianpi group and model group (P<0.05). Conclusions: Tumor can inhibit the expression of PKC inhibition. Yiqi Jianpi and anticancer treatment can reduce this inhibition. Besides this treatment can also inhibit expression of tumor related genes such as epidermal growth factor and vascular endothelial growth factor.
引用
收藏
页码:378 / 381
页数:4
相关论文
共 18 条
[1]
Al Faran A, 2013, RETINA, P102
[2]
Vascular endothelial growth factor as a therapeutic target in cancer [J].
Bergsland, EK .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2004, 61 (21) :S4-S11
[3]
Cong Bo, 2008, Zhonghua Yi Xue Za Zhi, V88, P2179
[4]
Expression of Vascular Endothelial Growth Factors C and D Correlates with Lymphangiogenesis and Lymph Node Metastasis in Lung Adenocarcinoma [J].
Cong Bo ;
Dong Xiaopeng ;
Peng Chuanliang ;
Zhao Xiaogang .
THORACIC AND CARDIOVASCULAR SURGEON, 2009, 57 (05) :291-294
[5]
Effects of Minocycline Plus Tissue Plasminogen Activator Combination Therapy After Focal Embolic Stroke in Type 1 Diabetic Rats [J].
Fan, Xiang ;
Lo, Eng H. ;
Wang, Xiaoying .
STROKE, 2013, 44 (03) :745-+
[6]
Jiang Ming, 2009, Sichuan Da Xue Xue Bao Yi Xue Ban, V40, P240
[7]
Li F, 2008, CONCISE COMBINE TRAD
[8]
Liu CM, 2000, J LIAONING TRAD CHIN, V27, P44
[9]
Lu Jian-jun, 2013, Zhonghua Wei Chang Wai Ke Za Zhi, V16, P1191
[10]
Mao Ying, 2013, Nan Fang Yi Ke Da Xue Xue Bao, V33, P1713