Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain

被引：50

作者：

Uemura, T

Mori, H

Mishina, M

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Mol Neurobiol & Pharmacol, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Corp, SORST, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 296卷 / 02期

关键词：

Golgi apparatus; DHHC zinc finger domain; protein trafficking; COS7; cells;

D O I：

10.1016/S0006-291X(02)00900-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified a novel Golgi apparatus-specific protein with the DHHC zinc finger domain and four putative transmembrane regions, designated as GODZ. The amino acid sequences were highly conserved among mouse and human GODZs and homologous proteins in human, mouse, rat, Drosophila melanogaster, and Caenorhabditis elegans, implying a functional significance of the GODZ protein family. Overexpression of mouse GODZ in COS7 cells suppressed the sorting of the glutamate receptor GluRalpha1 from the Golgi apparatus. These results suggest that GODZ plays a role in the membrane protein trafficking. (C) 2002 Elsevier Science (USA). All rights reserved.

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页码：492 / 496

页数：5

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