Endocrinology of anorexia of ageing

被引:71
作者
Chapman, IM [1 ]
机构
[1] Univ Adelaide, Royal Adelaide Hosp, Dept Med, Adelaide, SA 5000, Australia
关键词
sarcopaenia; cholecystokinin; anorexia; ghrelin; leptin; cytokines; testosterone; ageing;
D O I
10.1016/j.beem.2004.02.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Appetite and food intake decrease with normal ageing, predisposing to the development of under-nutrition. Under-nutrition is common in older people and has been implicated in the development and progression of chronic diseases commonly affecting the elderly, as well as in increasing mortality. An understanding of the factors that contribute to the physiological and pathological declines in food intake in older people is likely to aid in the development of effective forms of prevention and treatment. Ageing affects many of the endocrine factors involved in the control of appetite and feeding but few studies have been performed in humans to clarify these changes. Possible hormonal causes of the anorexia of ageing include increased activity of cholecystokinin, leptin and various cytokines and reduced activity of ghrelin and testosterone.
引用
收藏
页码:437 / 452
页数:16
相关论文
共 106 条
[1]   Preoperative supraphysiological testosterone in older men undergoing knee replacement surgery [J].
Amory, JK ;
Chansky, HA ;
Chansky, KL ;
Camuso, MR ;
Hoey, CT ;
Anawalt, BD ;
Matsumoto, AM ;
Bremner, WJ .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2002, 50 (10) :1698-1701
[2]   Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women [J].
Baranowska, B ;
Radzikowska, M ;
Wasilewska-Dziubínska, E ;
Roguski, K ;
Polonowski, A .
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2000, 7 (03) :149-155
[3]   Gut hormone PYY3-36 physiologically inhibits food intake [J].
Batterham, RL ;
Cowley, MA ;
Small, CJ ;
Herzog, H ;
Cohen, MA ;
Dakin, CL ;
Wren, AM ;
Brynes, AE ;
Low, MJ ;
Ghatei, MA ;
Cone, RD ;
Bloom, SR .
NATURE, 2002, 418 (6898) :650-654
[4]   Inhibition of food intake in obese subjects by peptide YY3-36 [J].
Batterham, RL ;
Cohen, MA ;
Ellis, SM ;
Le Roux, CW ;
Withers, DJ ;
Frost, GS ;
Ghatei, MA ;
Bloom, SR .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (10) :941-948
[5]   Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat [J].
Baumgartner, RN ;
Waters, DL ;
Morley, JE ;
Patrick, P ;
Montoya, GD ;
Garry, PJ .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (03) :378-384
[6]   KO's and organisation of peptidergic feeding behavior mechanisms [J].
Beck, B .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2001, 25 (02) :143-158
[7]   Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans [J].
Beglinger, C ;
Degen, L ;
Matzinger, D ;
D'Amato, M ;
Drewe, J .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (04) :R1149-R1154
[8]   Effect of growth hormone therapy on feeding problems and food intake in children with growth disorders [J].
Blissett, J ;
Harris, G ;
Kirk, J .
ACTA PAEDIATRICA, 2000, 89 (06) :644-649
[9]   GROWTH-HORMONE, EXERCISE, AND AGING - THE FUTURE OF THERAPY FOR THE FRAIL ELDERLY [J].
BORST, SE ;
MILLARD, WJ ;
LOWENTHAL, DT .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (05) :528-535
[10]   PEPTIDE CHOLESYSTOKININ RECEPTOR ANTAGONIST INCREASES FOOD-INTAKE IN RATS [J].
BRENNER, L ;
RITTER, RC .
APPETITE, 1995, 24 (01) :1-9