Yaoundamines A and B, new antimalarial naphthylisoquinoline alkaloids from Ancistrocladus korupensis

被引：23

作者：

Hallock, YF

Cardellina, JH

Schaffer, M

Stahl, M

Bringmann, G

Francois, G

Boyd, MR

机构：

[1] NCI,DIV CANC TREATMENT DIAG & CTR,DEV THERAPEUT PROGRAM,LAB DRUG DISCOVERY RES & DEV,FREDERICK,MD 21702

[2] UNIV WURZBURG,INST ORGAN CHEM,D-97074 WURZBURG,GERMANY

[3] INST TROP MED PRINCE LEOPOLD,B-2000 ANTWERP,BELGIUM

来源：

TETRAHEDRON | 1997年 / 53卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(97)00502-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New monomeric naphthylisoquinoline alkaloids, yaoundamines A and B, were isolated from Ancistrocladus korupensis and their structures were determined by extensive chemical and spectroscopic analyses. The absolute configuration at C3 was established by chemical degradation, while the axial chirality was deduced by comparison of experimental and calculated CD spectra. Yaoundamine B has an unprecedented glycosylated naphthylisoquinoline structure. Yaoundamines A and B are active in vitro against the malaria parasite Plasmodium falciparum. .

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收藏

页码：8121 / 8128

页数：8

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