Synthesis and Cytotoxicity Screening of Piperazine-1-carbodithioate Derivatives of 2-Substituted Quinazolin-4(3H)-ones

被引：17

作者：

Cao, Sheng-Li ^{[1
]}

Guo, Yan-Wen ^{[2
]}

Wang, Xian-Bo ^{[2
]}

Zhang, Mei ^{[1
]}

Feng, Yu-Ping ^{[3
]}

Jiang, Yu-Yang ^{[3
,4
]}

Wang, Yue ^{[3
,4
]}

Gao, Qian ^{[1
]}

Ren, Jian ^{[1
]}

机构：

[1] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China

[2] Beijing Inst Technol, Sch Sci, Beijing 100081, Peoples R China

[3] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[4] Tsinghua Univ, Grad Sch, Shenzhen 518057, Peoples R China

来源：

ARCHIV DER PHARMAZIE | 2009年 / 342卷 / 03期

关键词：

Dithiocarbamate; Cytotoxicity; Quinazolin-4(3H)-one; Screening; Synthesis; THYMIDYLATE SYNTHASE INHIBITORS; HETEROCYCLYLMETHYLAMINO-CARBODITHIOATE DERIVATIVES; VITRO ANTITUMOR-ACTIVITY; CRUCIFEROUS PHYTOALEXINS; C2; POSITION; 4-(3H)-QUINAZOLINONE; SUBSTITUENTS; CANCER; CHAINS; AGENTS;

D O I：

10.1002/ardp.200800148

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung cancer), HCT-8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.

引用

页码：182 / 189

页数：8

共 22 条

[1]

Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs [J].