Image contrast agents activated by prostate specific antigen (PSA)

被引：3

作者：

Jones, GB ^{[1
]}

Xie, LF

El-Shafey, A

Crasto, CF

Bubley, GJ

D'Amico, AV

机构：

[1] Northeastern Univ, Dept Chem & Chem Biol, Bioorgan & Med Chem Labs, Boston, MA 02115 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

[3] Dana Farber Canc Inst, Boston, MA 02215 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02215 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.bmcl.2004.04.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and alpha-chymotrypsin, releasing free fluorophore via cleavage of a three-component system. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3081 / 3084

页数：4

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