Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

被引：275

作者：

Calcutt, Nigel A. ^{[1
]}

Cooper, Mark E. ^{[2
]}

Kern, Tim S. ^{[3
]}

Schmidt, Ann Marie ^{[4
]}

机构：

[1] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[2] Baker IDI Heart & Diabet Inst, Diabet Div, Melbourne, Vic 3004, Australia

[3] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA

[4] Columbia Univ, Coll Phys & Surg, New York, NY 10032 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 05期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

GLYCATION END-PRODUCTS; ALDOSE REDUCTASE INHIBITION; NERVE GROWTH-FACTOR; RENIN-ANGIOTENSIN SYSTEM; ALTERED GENE-EXPRESSION; DORSAL-ROOT GANGLIA; PERIPHERAL-NERVE; NEUROPATHIC PAIN; RENAL-DISEASE; IMMUNOHISTOCHEMICAL LOCALIZATION;

D O I：

10.1038/nrd2476

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Long-term diabetes increases the likelihood of developing secondary damage to numerous systems, and these complications represent a substantial cause of morbidity and mortality. Establishing the causes of diabetes remains the key step towards eradicating the disease, but the prevention and amelioration of diabetic complications is equally important for the millions of individuals who already have the disease or are likely to develop it before prophylaxis or a cure become routinely available. In this Review, we focus on four common complications of diabetes, discuss the range of pathologies that are precipitated by hyperglycaemia and highlight emerging targets for therapeutic intervention.

引用

页码：417 / 429

页数：13

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