Free radicals and brain aging

被引：222

作者：

Poon, HF

Calabrese, V

Scapagnini, G

Butterfield, DA

机构：

[1] Univ Kentucky, Dept Chem, Ctr Membrane Sci, Lexington, KY 40506 USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[3] Univ Catania, Fac Med, Sect Biochem & Mol Biol, Dept Chem, I-95123 Catania, Italy

[4] CNR, Inst Neurol Sci, I-95123 Catania, Italy

来源：

CLINICS IN GERIATRIC MEDICINE | 2004年 / 20卷 / 02期

关键词：

D O I：

10.1016/j.cger.2004.02.005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is a common risk factor for neurodegenerative diseases. The free radical theory of aging states that functional impairments are due to the reaction of critical cellular components with free radicals, reactive oxygen species (ROS), and reactive nitrogen species (RNS). We examine the formation of major ROS (O-2(-), HO., HOCl, and H2O2) and RNS (NO, ONOO-, and NO2). We then examine two endogenous antioxidants systems (glutathione and heat-shock proteins) that are decreased in age-related neurodegenerative disorders. Finally, we review the evidence of age-related, free radical-mediated damage to the brain, emphasizing lipid peroxidation and protein oxidation. We conclude that free radical-mediated lipid peroxidation and protein oxidation are at least partially responsible for the deterioration of the central nervous system in aging.

引用

页码：329 / +

页数：32

共 264 条

[1] AGING AND PROTEOLYSIS OF OXIDIZED PROTEINS [J].