HEp-2-adherent Escherichia coli strains associated with acute infantile diarrhea, Sao Paulo, Brazil

被引：54

作者：

Scaletsky, ICA ^{[1
]}

Fabbricotti, SH ^{[1
]}

Silva, SOC ^{[1
]}

Morais, MB ^{[1
]}

Fagundes-Neto, U ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil

来源：

EMERGING INFECTIOUS DISEASES | 2002年 / 8卷 / 08期

关键词：

D O I：

10.3201/eid0808.010492

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this paired case-control study of infants with diarrhea in Sao Paulo, we examined the association between HEp-2-adherent Escherichia coli strains and diarrhea. We tested isolates from stool specimens of infants with diarrhea and matched controls in an HEp-2 cell adherence assay; we then hybridized isolates with DNA probes and identified enteropathogenic E coli (EPEC), enteroaggregative E. coli (EAEC), and diffusely adherent E coli (DAEC). From 100 patient-control pairs, we isolated 78 HEp-2-adherent strains; of these, 61 strains were single pathogens identified in stools of infants with diarrhea. While typical EPEC was significantly associated with diarrhea (p<0.001), EAEC was more frequently associated with diarrhea in clinical cases (20%) compared with healthy controls (3%) (p<0.001). Atypical EPEC, showing a localized adherence-like pattern, was also more common in patients than controls (p>0.1). DAEC was isolated with equal frequency from patients and controls (p>0.1).

引用

页码：855 / 858

页数：4

共 19 条

[1] A SENSITIVE AND SPECIFIC DNA PROBE TO IDENTIFY ENTEROAGGREGATIVE ESCHERICHIA-COLI, A RECENTLY DISCOVERED DIARRHEAL PATHOGEN [J].