Antinociceptive substances from Incarvillea delavayi

被引：45

作者：

Nakamura, M ^{[1
]}

Kido, K ^{[1
]}

Kinjo, J ^{[1
]}

Nohara, T ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 02期

关键词：

Incarvillea delavayi; bignoniaceae; monoterpene alkaloid; iridoid; antinociception;

D O I：

10.1016/S0031-9422(99)00536-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antinociceptive activities of an Incarvillea delavayi extract, as well as its constituents, 8-epideoxyloganic acid and delavayine A, were evaluated in the acetic acid induced writhing test in mice. An oral administration of the delavayi extract weakly decreased the number of writhings and stretchings in this test, in a dose-dependent manner. Furthermore, orally administered 8-epideoxyloganic acid showed weak antinociceptive activity, whereas administration by subcutaneous injection did not. However, subcutaneous injection of delavayine A, a novel monoterpene alkaloid, showed a more significant level of antinociceptive activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：253 / 256

页数：4

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