VEINES-QOL/Sym questionnaire was a reliable and valid disease-specific quality of life measure for deep venous thrombosis

被引:152
作者
Kahn, Susan R. [1 ]
Lamping, Donna L.
Ducruet, Thierry
Arsenault, Louise
Miron, Marie Jose
Roussin, Andre
Desmarais, Sylvie
Joyal, France
Kassis, Jeannine
Solymoss, Susan
Desjardins, Louis
Johri, Mira
Shrier, Ian
机构
[1] Jewish Gen Hosp, Ctr Clin Epidemiol & Community Studies, Montreal, PQ, Canada
[2] McGill Univ, Montreal, PQ, Canada
[3] London Sch Hyg & Trop Med, Hlth Serv Res Unit, London WC1, England
[4] Univ Montreal, Montreal, PQ, Canada
[5] Ctr Hosp Pierre Boucher, Longueuil, PQ, Canada
[6] Univ Laval, Quebec City, PQ G1K 7P4, Canada
关键词
venous thromboembolism; deep vein thrombosis; quality of life; questionnaire; patient outcomes; outcomes research;
D O I
10.1016/j.jclinepi.2005.10.016
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: To assess the validity of VEINES-QOL/Sym, a patient-reported questionnaire to evaluate quality of life and symptoms in patients with deep venous thrombosis (DVT). Study Design and Setting: Psychometric study within the Venous Thrombosis Outcomes (VETO) Study, a prospective cohort study of long-term outcomes after DVT. A total of 359 English- and French-speaking patients with acute, objectively diagnosed DVT were recruited at seven hospitals in Quebec, Canada. The VEINES-QOL/Sym questionnaire, a 26-item patient-reported measure that generates separate summary scores for symptoms (VEINES-Sym) and quality of life (VEINES-QOL) was evaluated for acceptability, reliability, validity, and responsiveness in VETO Study subjects. Results: Standard psychometric tests confirmed the acceptability (missing data, item endorsement frequencies, floor and ceiling effects), reliability (internal consistency, item-total and inter-item correlations, test-retest), validity (content, construct, convergent, discriminant, known groups), and responsiveness to clinical change of the VEINES-QOL/Sym in patients with DVT. Conclusion: The VEINES-QOL/Sym is a practical and scientifically sound patient-reported measure of outcomes that was developed using gold-standard methods. VEINES-QOL/Sym is valid and reliable for use as a measure of quality of life and symptoms in patients with acute DVT and provides a rigorous tool to allow more comprehensive evaluation of outcomes in clinical trials and epidemiological studies of patients with DVT. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:1049 / 1056
页数:8
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