Mycobacterial lipoarabinomannans:: modulators of dendritic cell function and the apoptotic response

被引：120

作者：

Nigou, J

Gilleron, M

Rojas, M

García, LF

Thurnher, M

Puzo, G

机构：

[1] CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France

[2] Univ Antioquia, Fac Med, Grp Inmunol Celulare Inmunogenet, Medellin, Colombia

[3] Univ Innsbruck, Dept Urol, A-6020 Innsbruck, Austria

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 09期

关键词：

lipoarabinomannan; IL-12; apoptosis;

D O I：

10.1016/S1286-4579(02)01621-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：945 / 953

页数：9

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