Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infection

被引：22

作者：

Casper, C

Krantz, E

Taylor, H

Dalessio, J

Carrell, D

Wald, A

Corey, L

Ashley, R

机构：

[1] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA

[3] Univ Washington, Sch Med, Dept Epidemiol, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98104 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2002年 / 40卷 / 10期

关键词：

D O I：

10.1128/JCM.40.10.3822-3825.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The performance of a human herpesvirus 8 (HHV-8) enzyme immunoassay (EIA) and selective subsequent use of an HHV-8 immunofluorescence assay (IFA) was tested in persons unlikely to be infected with HHV-8 and those who had HHV-8 detected in their saliva. The IFA was performed on samples within a range of EIA optical densities (0.15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%.

引用

页码：3822 / 3825

页数：4

共 19 条

[1] Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs [J].