Synthesis of β-lactam scaffolds for ditopic peptidomimetics

被引：45

作者：

Palomo, Claudio ^{[1
]}

Aizpurua, Jesus M. ^{[1
]}

Balentova, Eva ^{[1
]}

Jimenez, Azucena ^{[1
]}

Oyarbide, Joseba ^{[1
]}

Fratila, Raluca M. ^{[1
]}

Ignacio Miranda, Jose ^{[1
]}

机构：

[1] Univ Basque Country, Dept Quim Organ 1, Fac Quim, Sa Sebastian 20080, Spain

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 01期

关键词：

D O I：

10.1021/ol0626241

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ring opening of alpha-substituted-alpha-methoxycarbonyl-N-nosylaziridines provides a practical access to enantiopure alpha,alpha'-disubstituted beta-lactam scaffolds, novel types of ditopic reverse turn surrogates. The procedure is general, short, and high yielding and starts from handy alpha-substituted serinates and alpha-amino acid derivatives.

引用

页码：101 / 104

页数：4

共 37 条

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