Synthesis of β-lactam scaffolds for ditopic peptidomimetics

被引:45
作者
Palomo, Claudio [1 ]
Aizpurua, Jesus M. [1 ]
Balentova, Eva [1 ]
Jimenez, Azucena [1 ]
Oyarbide, Joseba [1 ]
Fratila, Raluca M. [1 ]
Ignacio Miranda, Jose [1 ]
机构
[1] Univ Basque Country, Dept Quim Organ 1, Fac Quim, Sa Sebastian 20080, Spain
关键词
D O I
10.1021/ol0626241
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Ring opening of alpha-substituted-alpha-methoxycarbonyl-N-nosylaziridines provides a practical access to enantiopure alpha,alpha'-disubstituted beta-lactam scaffolds, novel types of ditopic reverse turn surrogates. The procedure is general, short, and high yielding and starts from handy alpha-substituted serinates and alpha-amino acid derivatives.
引用
收藏
页码:101 / 104
页数:4
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