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Linezolid penetration into osteo-articular tissues

被引：94
作者：
Rana, B
Butcher, I
Grigoris, P
Murnaghan, C
Seaton, RA
Tobin, CM
机构：
[1] Univ Glasgow, Western Infirm, Dept Orthopaed, Glasgow G11 6NT, Lanark, Scotland
[2] Univ Glasgow, Western Infirm, Dept Microbiol, Glasgow G11 6NT, Lanark, Scotland
[3] Univ Glasgow, Western Infirm, Dept Infect Dis, Glasgow G11 6NT, Lanark, Scotland
[4] Gartnavel Royal Hosp, Glasgow G11 6NT, Lanark, Scotland
[5] Southmead Gen Hosp, Dept Microbiol, Bristol Ctr Antimicrobial Res & Evaluat, Bristol BS10 5NB, Avon, England
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 50卷 / 05期
关键词：
linezolid; oxazolidinone; bone and joint infection; osteomyelitis; osteo-articular tissue; pharmacokinetics;
D O I：
10.1093/jac/dkf207
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Penetration of linezolid into osteo-articular tissue and fluid was studied in 10 patients undergoing primary total knee replacement. Linezolid 600 mg 12 hourly was given orally over the 48 h before operation and intravenously 1 h before induction of anaesthesia. Mean concentrations of linezolid at 90 min after the final dose, in serum, synovial fluid, synovium, muscle and cancellous bone, assayed by HPLC, were at least twice the MIC90 for staphylococci and streptococci. The concentrations obtained indicate good penetration of this antibiotic and support its use in the management of multidrug-resistant Gram-positive bone, joint and deep-seated soft-tissue infections.
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收藏
页码：747 / 750
页数：4
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