CD8αα-mediated survival and differentiation of CD8 memory T cell precursors

被引：162

作者：

Madakamutil, LT

Christen, U

Lena, CJ

Wang-Zhu, YR

Attinger, A

Sundarrajan, M

Ellmeier, W

von Herrath, MG

Jensen, P

Littman, DR

Cheroutre, H

机构：

[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

[2] NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA

[3] NYU, Sch Med, Skirball Inst Biomed Sci, New York, NY 10016 USA

[4] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

SCIENCE | 2004年 / 304卷 / 5670期

关键词：

D O I：

10.1126/science.1092316

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta(+) T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha.

引用

收藏

页码：590 / 593

页数：4

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