Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw

被引:23
作者
Amann, R [1 ]
Schuligoi, R [1 ]
机构
[1] Graz Univ, Dept Expt & Clin Pharmacol, A-8010 Graz, Austria
基金
奥地利科学基金会;
关键词
cyclooxygenase; inflammation; neurotrophin; non-steroidal antiphlogistic drugs; prostaglandin;
D O I
10.1016/S0304-3940(99)00931-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It is known that the concentration of nerve growth factor (NGF) is increased in inflamed tissue, a phenomenon thought to induce long-lasting sensitization of afferent neurons. Although the effects of NGF may be of pathophysiological relevance, there is little known about the effects of non-steroidal anti-inflammatory drugs on the inflammation-induced increase in NGF. In the present study, therefore, we used the non-steroidal anti-inflammatory drugs indomethacin and sodium salicylate in carrageenan-induced rat paw inflammation, in order to compare their anti-inflammatory action (determined as inhibition of edema) with their effects on the concentration of NGF in inflamed tissue. Carrageenan induced inflammation increased the concentration of NGF in the paw 2-fold compared to non-inflamed controls. Indomethacin (0.66-2 mg/kg) and sodium salicylate (100-300 mg/kg) inhibited carrageenan-induced paw edema and indomethacin also inhibited the ex-vivo release of immunoreactive prostaglandin E-2 from inflamed paw skin. However, at these doses, neither anti-inflammatory agent reduced the elevated levels of NGF. In contrast, a supramaximal dose of indomethacin (6 mg/kg) partially inhibited, and dexamethasone completely prevented the carrageenan-induced increase in NGF. These results suggest that the anti-inflammatory potency of drugs as determined in the carrageenan edema model is not necessarily predictive for their ability to inhibit the NGF response. it seems possible, therefore, that even if anti-inflammatory treatment prevents the appearance of visible signs of inflammation, there may be still long-lasting effects of NGF on the phenotype of primary afferent neurons. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:173 / 176
页数:4
相关论文
共 17 条
[1]   ANTIINFLAMMATORY ACTION OF SALICYLATES - ASPIRIN IS NOT A PRODRUG FOR SALICYLATE AGAINST RAT CARRAGEENIN PLEURISY [J].
CHIABRANDO, C ;
CASTELLI, MG ;
COZZI, E ;
FANELLI, R ;
CAMPOLEONI, A ;
BALOTTA, C ;
LATINI, R ;
GARATTINI, S .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 159 (03) :257-264
[2]   Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFκB [J].
Cronstein, BN ;
Montesinos, MC ;
Weissmann, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) :6377-6381
[3]   INCREASED CONTENT AND TRANSPORT OF SUBSTANCE-P AND CALCITONIN GENE-RELATED PEPTIDE IN SENSORY NERVES INNERVATING INFLAMED TISSUE - EVIDENCE FOR A REGULATORY FUNCTION OF NERVE GROWTH-FACTOR INVIVO [J].
DONNERER, J ;
SCHULIGOI, R ;
STEIN, C .
NEUROSCIENCE, 1992, 49 (03) :693-698
[4]   PHARMACOKINETICS OF ASPIRIN AND SALICYLATE IN RELATION TO INHIBITION OF ARACHIDONATE CYCLOOXYGENASE AND ANTIINFLAMMATORY ACTIVITY [J].
HIGGS, GA ;
SALMON, JA ;
HENDERSON, B ;
VANE, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1417-1420
[5]  
Kerr BJ, 1999, J NEUROSCI, V19, P5138
[6]   PERIPHERAL AND CENTRAL MECHANISMS OF NGF-INDUCED HYPERALGESIA [J].
LEWIN, GR ;
RUEFF, A ;
MENDELL, LM .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (12) :1903-1912
[7]   THE BIOLOGICAL EFFECTS OF ENDOGENOUS NERVE GROWTH-FACTOR ON ADULT SENSORY NEURONS REVEALED BY A TRKA-IGG FUSION MOLECULE [J].
MCMAHON, SB ;
BENNETT, DLH ;
PRIESTLEY, JV ;
SHELTON, DL .
NATURE MEDICINE, 1995, 1 (08) :774-780
[8]   Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder [J].
Oddiah, D ;
Anand, P ;
McMahon, SB ;
Rattray, M .
NEUROREPORT, 1998, 9 (07) :1455-1458
[9]   Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion [J].
Pillinger, MH ;
Capodici, C ;
Rosenthal, P ;
Kheterpal, N ;
Hanft, S ;
Philips, MR ;
Weissmann, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14540-14545
[10]   CONTRIBUTION OF INTERLEUKIN-1-BETA TO THE INFLAMMATION-INDUCED INCREASE IN NERVE GROWTH-FACTOR LEVELS AND INFLAMMATORY HYPERALGESIA [J].
SAFIEHGARABEDIAN, B ;
POOLE, S ;
ALLCHORNE, A ;
WINTER, J ;
WOOLF, CJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (07) :1265-1275