Variants of NOS1, NOS2, and NOS3 genes in asthmatics

被引：61

作者：

Gao, PS

Kawada, H

Kasamatsu, T

Mao, XQ

Roberts, MH

Miyamoto, Y

Yoshimura, M

Saitoh, Y

Yasue, H

Nakao, K

Adra, CN

Kun, JF

Moro-oka, S

Inoko, H

Ho, LP

Shirakawa, T ^{[1
]}

Hopkin, JM

机构：

[1] Univ Wales, Expt Med Unit, Swansea, W Glam, Wales

[2] Tokai Univ, Dept Genet Informat, Div Mol Life Sci, Isehara, Kanagawa, Japan

[3] Sakai Chem Corp, Div Pharmaceut, Sakai, Osaka, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto, Japan

[5] Kumamoto Univ, Sch Med, Div Cardiol, Kumamoto 860, Japan

[6] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA USA

[7] Univ Tubingen, Inst Trop Med, Dept Parasitol, Tubingen, Germany

[8] Churchill Hosp, Osler Chest Unit, Oxford OX3 7LJ, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 267卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/bbrc.1999.2030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics, NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI: 1.20-3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels, Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population. (C) 2000 Academic Press.

引用

页码：761 / 763

页数：3

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