Induction of pulmonary cytochrome P4501A1:: interactive effects of nicotine and mecamylamine

被引：8

作者：

Iba, MM ^{[1
]}

Fung, J ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Pharmacol & Toxicol, Coll Pharm, EOHSI, Piscataway, NJ 08854 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 383卷 / 03期

关键词：

nicotine; mecamylamine; pulmonary cytochrome P4501A1; induction; antagonism;

D O I：

10.1016/S0014-2999(99)00639-1

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The effect of the nicotinic receptor antagonist mecamylamine on nicotine-mediated convulsions and induction of pulmonary cytochrome P4501A1 (CYP1A1) was examined in the rat. Mecamylamine blocked the convulsions and inhibited CYP1A1 induction by nicotine at the level of CYP1A1 activity (93%) and protein (97%), but independently induced the enzyme also at the level of activity and protein. The results show that mecamylamine antagonizes both the CYP1A1 induction and convulsions by nicotine but, independently, is an inducer of the enzyme. The results indicate that CYP1A1 induction is not a consequence of the convulsant effects of nicotine. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：399 / 403

页数：5

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