FLASH is an essential component of Cajal bodies

被引：51

作者：

Barcaroli, D.

Dinsdale, D.

Neale, M. H.

Bongiorno-Borbone, L.

Ranalli, M.

Munarriz, E.

Sayan, A. E.

McWilliam, J. M.

Smith, T. M.

Fava, E.

Knight, R. A.

Melino, G.

De Laurenzi, V.

机构：

[1] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

[2] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy

[3] Ctr Europeo Ric Cervello, Ist Ricovero & Cura Carattere Sci, Fdn S Lucia, I-00143 Rome, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 40期

基金：

英国医学研究理事会;

关键词：

coiled bodies; nuclear organelles;

D O I：

10.1073/pnas.0604225103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.

引用

页码：14802 / 14807

页数：6

共 31 条

[1] FLASH is required for histone transcription and S-phase progression [J].