Efficacy of calcipotriol ointment applied under hydrocolloid occlusion in psoriasis

Background: Hydrocolloid (HCD) dressings enhance the efficacy of topical corticosteroids. Objective: We wanted to evaluate the effect of calcipotriol ointment under an HCD dressing in the treatment of psoriatic plaques. Methods: In 9 psoriatic patients, we cleared one plaque using this approach and took biopsies at start, clearance and relapse, Clinical and immunohistochemical validation was assessed. Results: After an average treatment of 3.6 weeks, each lesion had cleared (apart from some residual erythema). The average remission period was 8 weeks. During this treatment, the number of cycling epidermal cells (Ki-67-positive nuclei) and the expression of keratin 14 and keratin 16 had decreased substantially. In biopsies taken from the skin immediately adjacent to the relapsing lesion, these markers remained reduced which indicated the prolonged effect of calcipotriol on epidermal differentiation. Conclusion: It is speculated that combination therapy of calcipotriol with treatments with a different mode of action such as photo(chemo)therapy, corticosteroids and cyclosporine might be worthwhile. Copyright (R) 2000 S. Karger AG, Basel.