Molecular cloning and expression analysis of a cDNA encoding a glutamate transporter in the honeybee brain

被引：46

作者：

Kucharski, R ^{[1
]}

Ball, EE ^{[1
]}

Hayward, DC ^{[1
]}

Maleszka, R ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Biol Sci, Mol Genet & Evolut Grp, Canberra, ACT 0200, Australia

来源：

GENE | 2000年 / 242卷 / 1-2期

关键词：

Apis mellifera; EAAT; Kenyon cells; mushroom bodies;

D O I：

10.1016/S0378-1119(99)00503-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have cloned and characterized a cDNA encoding a putative glutamate transporter, Am-EAAT, from the brain of the honeybee, Apis mellifera. The 543-amino-acid AmEAAT gene product shares the highest sequence identity (54%) with the human EAAT2 subtype. Am-EAAT is expressed predominantly in the brain, and its transcripts are abundant in the optic lobes and inner compact Kenyon cells of the mushroom bodies (MBs), with most other regions of the brain showing lower levels of Am-EAAT expression. High levels of Am-EAAT message are found in pupal stages, possibly indicating a role for glutamate in the developing brain. (C) 2000 Elsevier Science B.V. AII rights reserved.

引用

页码：399 / 405

页数：7

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