A NOVEL BONE SCAFFOLDS BASED ON HYPERBRANCHED POLYGLYCEROL FIBERS FILLED WITH HYDROXYAPATITE NANOPARTICLES: IN VITRO CELL RESPONSE

被引：7

作者：

Alencar de Queiroz, Alvaro Antonio ^{[1
]}

Bressiani, Jose Carlos ^{[2
]}

Bressiani, Ana Helena ^{[2
]}

Higa, Olga Zazuco ^{[3
]}

Abraham, Gustavo Abel ^{[4
]}

机构：

[1] Univ Fed Itajuba UNIFEI, Dept Quim & Fis, Inst Ciencias Exatas, Av BPS 1303, BR-37500903 Itajuba, MG, Brazil

[2] Inst Pesquisas Energet Nucl, Ctr Ciencia Technol Mat, BR-05508000 Sao Carlos, SP, Brazil

[3] Inst Pesquisas Energet Nucl, Ctr Biotechnol, BR-05508000 Sao Carlos, SP, Brazil

[4] Inst Invest Ciencia Technol Mat, Mar Del Plata, Buenos Aires, Argentina

来源：

BIOCERAMICS 21 | 2009年 / 396-398卷

关键词：

Hyperbranched polyglycerol; Electrospun; Scaffolds; Hydroxyapatite; Tissue engineering; Hydrogels;

D O I：

10.4028/www.scientific.net/KEM.396-398.633

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel bone scaffolding material was successfully fabricated by electrospinning from hyperbranched polyglycerol (HPGL) solutions containing nanoparticles of hydroxyapatite (HA). The potential use of the electrospun fibrous HPGL-HA scaffolds for bone regeneration was evaluated in vitro with human osteoblasts in terms of alkaline phosphatase (ALP) activity of the cells that were cultured directly on the scaffolds. The results were compared with those on corresponding HPLG-HA solution-cast film scaffolds. It was found that all of the fibrous scaffolds promoted much better adhesion and proliferation of cells than the corresponding film scaffolds.

引用

页码：633 / 636

页数：4

共 11 条

[1]

[Anonymous], 1999, ISO 10993-5

[2] The effect of conjugated linoleic acid on the viability and metabolism of human osteoblast-like cells [J].

Cusack, S ;

Jewell, C ;

Cashman, KD .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2005, 72 (01) :29-39

[3]

DUNITRIU S, 2002, POLYM BIOMATERIALS

[4] Effect of Mg2+ addition during HA nanoparticles synthesis using ultrasonic irradiation [J].

Gouveia, D. S. ;

Coutinho, A. C. S. ;

Bressiani, A. H. A. ;

Bressiani, J. C. .

BIOCERAMICS, VOL 20, PTS 1 AND 2, 2008, 361-363 :203-206

[5]

Hsu FY, 1999, BIOMATERIALS, V20, P1931

[6]

STIRIBA SE, 2000, J AM CHEM SOC, V122, P2954

[7]

Sunder A, 1999, ANGEW CHEM INT EDIT, V38, P2928, DOI 10.1002/(SICI)1521-3773(19991004)38:19<2928::AID-ANIE2928>3.0.CO

[8]

2-#

[9] Reaction of dextran with glycidyl methacrylate: An unexpected transesterification [J].

vanDijkWolthuis, WNE ;

KettenesvandenBosch, JJ ;

vanderKerkvanHoof, A ;

Hennink, WE .

MACROMOLECULES, 1997, 30 (11) :3411-3413

[10] Aligned biodegradable nanotibrous structure: a potential scaffold for blood vessel engineering [J].

Xu, CY ;

Inai, R ;

Kotaki, M ;

Ramakrishna, S .

BIOMATERIALS, 2004, 25 (05) :877-886

← 1 2 →